Tracking Research: Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex

Tracking Research: Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex

GA Rodriguez, MP Burns, EJ Weeber… - Learning & …, 2013 - learnmem.cshlp.org

Young APOE4 TR mice exhibit impaired spatial learning and memory in
the Barnes maze. ... However, E2 and E4 performance in a single probe trial was affected.
Eighteen-month-old APOE4 TR mice exhibit spatial learning deficits in the Barnes maze. ...